Study Suggests Link Between Higher Tyrosine Levels and Shorter Lifespan in Men
A recent study indicates that genetically higher levels of tyrosine, a common ingredient in cognitive enhancement supplements, may be associated with a shorter lifespan in men. Researchers from the University of Hong Kong and the University of Georgia analyzed data from over 250,000 individuals in the UK Biobank, finding that men with elevated tyrosine levels lived approximately one year less on average. This finding raises questions about the long-term health implications of using tyrosine, despite its reported short-term benefits for stress management and memory.
A new study has explored the potential long-term health implications of tyrosine, a nonessential amino acid often found in dietary supplements and energy products for cognitive enhancement.
The research, published in *Aging* last fall, involved scientists from the University of Hong Kong and the University of Georgia. They analyzed data from more than 250,000 individuals registered in the UK Biobank, a comprehensive health database.
Using Mendelian randomization, a technique that assesses causal relationships based on genetic differences, the study initially linked increased levels of both phenylalanine and tyrosine to a higher risk of earlier death. After accounting for overlapping effects, only tyrosine consistently pointed toward a shorter lifespan.
Specifically, the study found that men with genetically higher tyrosine levels lived, on average, about 0.9 years less than those with normal levels. The association was less clear in women, and the study noted that men tend to have naturally higher tyrosine levels.
Tyrosine is crucial for producing brain chemicals such as dopamine and adrenaline, which regulate mood, focus, and stress response. It is converted from phenylalanine, an amino acid present in protein-rich foods like meat, eggs, dairy, beans, and soy.
Scientists suggested potential mechanisms for tyrosine's influence on lifespan, including insulin resistance, a condition linked to diabetes and age-related illnesses. A previous study involving children had connected high tyrosine levels to decreased insulin sensitivity. Additionally, tyrosine's interaction with stress pathways and adrenaline-related neurotransmitters might accelerate aging.
Despite these findings, L-tyrosine is widely promoted in dietary supplements for its cognitive benefits, including easing stress and improving memory. Previous research has supported these claims, showing improved cognitive flexibility and memory retention in individuals taking L-tyrosine supplements during mentally demanding tasks.
However, the new research prompts a reevaluation of whether the short-term cognitive benefits of tyrosine outweigh potential long-term health risks.
According to Fast Company, this article originally appeared on their sister website, Inc.com.
